Spero Therapeutics, Inc.

SPRONASDAQHealthcare● Active

$2.74

$-0.08(-2.84%)

Market Cap$158650091

P/E Ratio—

52W High$3.22

52W Low$1.8

Avg Volume524K

Open$2.84

Beta1.46

Employees Ownership Insider Trades

Spero Therapeutics, Inc. (SPRO) Number of Employees – History & Annual Headcount

Annual SEC headcount, year-over-year change, and per-employee efficiency — chart and full history below.

SEC EDGAR · FMP · SPRO · as of Mar 26, 2026

Latest filing snapshot

-7-21.88%vs prior year

Spero Therapeutics, Inc. (SPRO) employee data is sourced from the annual SEC 10-K filing. As of 2025, full-time employees only. Global consolidated headcount. View SEC filing ↗

SEC 10-K·Period end: 2025-12-31·Full-time · Global

Total Employees

Change (1Y)

-7

Growth % (1Y)

-21.88%

Revenue / Employee

$2.38M

Net Income / Employee

$342.9K

Market Cap

$159M

SPRO Employee Count

2017 – 2025 · Annual · SEC filing

Source: SEC annual filings · Hover bar to view year data · Click to view original filing

Employees History

Filing Date	Period End	Employees	Change (1Y)	Growth (1Y)
2026-03-26	2025-12-31	25	-7	-21.88%
2025-03-27	2024-12-31	32	-14	-30.43%
2024-03-13	2023-12-31	46	+11	+31.43%
2023-03-30	2022-12-31	35	-111	-76.03%
2022-03-31	2021-12-31	146	+57	+64.04%
2021-03-11	2020-12-31	89	+32	+56.14%
2020-03-16	2019-12-31	57	+16	+39.02%
2019-03-14	2018-12-31	41	+6	+17.14%
2018-04-02	2017-12-31	35	—	—

▸ Source: SEC Annual Reports (Form 10-K / 20-F). Employee counts as of fiscal year end. Click the ↗ icon at the end of a row to open the original SEC filing in a new tab.

Related Companies — Employee Count

Biotechnology

#SymbolCompanyEmployeesMkt Cap

INO

Inovio Pharmaceuticals, Inc.

134$58M #2

ABOS

Acumen Pharmaceuticals, Inc.

61$131M #3

CRBP

Corbus Pharmaceuticals Holdings, Inc.

28$95M #4

SPRO

Spero Therapeutics, Inc.YOU

25$159M #5

CGTX

Cognition Therapeutics, Inc.

25$89M #6

HURA

TuHURA Biosciences, Inc.

19$130M #7

ACTU

Actuate Therapeutics Inc

10$44M

Source: /stock-peers + /profile.fullTimeEmployees · Click row → /employees · Sorted by headcount · SPRO peer comparison

About SPRO employees

SPRO Employees · Headcount

Spero Therapeutics, Inc. (SPRO) employee data is sourced from the annual SEC 10-K filing. As of 2025, Spero Therapeutics, Inc. had 25 full-time employees globally. Full-time employees only. Global consolidated headcount.

Spero Therapeutics, Inc. employs 25 full-time employees as of the latest filing within the Biotechnology industry. Revenue per employee stands at $2.38M, reflecting the company's operational efficiency.

Spero Therapeutics, Inc.'s workforce decreased by 7 (21.88%) in 2025 compared to the prior fiscal year. The historical trend reflects the company's expansion and contraction cycles.

Spero Therapeutics, Inc.'s revenue per employee of $2.38M positions it among the notable performers in the Biotechnology sector for operational efficiency.

Revenue Financial statements Net income SEC filings Price history Forecast & ratings Ownership Earnings

Frequently Asked Questions

SPRO Employees · 5 questions

As of the latest SEC 10-K filing (2025), Spero Therapeutics, Inc. had 25 full-time employees globally. This figure is sourced from the company's mandatory annual disclosure to the SEC.

Spero Therapeutics, Inc. employee counthow many employees does Spero Therapeutics, Inc. haveSPRO total employees 2025

▸ Data source: FMP /historical-employee-count · SEC EDGAR annual filings · As reported · Global consolidated headcount · As of 2026-03-26