Spero Therapeutics, Inc.
Spero Therapeutics, Inc. (SPRO) PE Ratio — Current & Historical Data
Trailing twelve months (TTM) P/E, forward P/E, PEG, and annual PE history — from market prices and filings.
spro · pe ratio · data through Dec 31, 2025
Core PE Ratio Metrics
Trailing 12 months · TTMThe price-to-earnings (P/E) ratio for Spero Therapeutics, Inc. (SPRO) measures how much investors pay for each dollar of the company's trailing earnings. SPRO's current PE ratio of 10.30x is calculated by dividing its stock price of $2.74 by its TTM earnings per share of $0.27. +10.7% elevated vs 5Y avg 9.3x
Source: FMP · /ratios-ttm · /analyst-estimates · 2025-12-31
PE Ratio History
2015 – 2025 · Annual▸ FMP /ratios?period=annual&limit=20 · priceToEarningsRatio + netIncomePerShare (Annual)
PE Ratio vs Peers
Biotechnology · 6 peers · Annual PE| Company | Market Cap | PE (Annual) | vs Avg | EPS (TTM) |
|---|---|---|---|---|
Spero Therapeutics, Inc.You SPRO | $159M | 10.30x | — | $0.27 |
 Acumen Pharmaceuticals, Inc. ABOS | $131M | N/A | — | -$2.00 |
 Actuate Therapeutics Inc ACTU | $44M | N/A | — | -$1.06 |
 Cognition Therapeutics, Inc. CGTX | $89M | N/A | — | -$0.32 |
 Corbus Pharmaceuticals Holdings, Inc. CRBP | $95M | N/A | — | -$5.90 |
 TuHURA Biosciences, Inc. HURA | $130M | N/A | — | -$0.63 |
 Inovio Pharmaceuticals, Inc. INO | $58M | N/A | — | -$0.18 |
* N/A — Company is not profitable (TTM) · excluded from industry average · ▸ FMP /stock-peers + /ratios?limit=1 · priceToEarningsRatio
Annual PE Ratio History
| Fiscal Year End | PE Ratio | EPS (TTM) | YoY Change | PE vs Max |
|---|---|---|---|---|
2025-12-31Latest FY2025 | 15.23x | $0.15 | — | |
2024-12-31 FY2024 | — | $-1.27 | — | |
2023-12-31 FY2023 | 3.40x | $0.43 | — | |
2022-12-31 FY2022 | — | $-1.23 | — | |
2021-12-31 FY2021 | — | $-2.91 | — | |
2020-12-31 FY2020 | — | $-3.50 | — | |
2019-12-31 FY2019 | — | $-3.35 | — | |
2018-12-31 FY2018 | — | $-2.60 | — | |
2017-12-31 FY2017 | — | $-17.82 | — | |
2016-12-31 FY2016 | — | $-3.86 | — |
▸ FMP /ratios?period=annual&limit=20 · priceToEarningsRatio + netIncomePerShare · Zero extra API
About PE Ratio & Methodology
The price-to-earnings (P/E) ratio for Spero Therapeutics, Inc. (SPRO) measures how much investors pay for each dollar of the company's trailing earnings. SPRO's current PE ratio of 10.30x is calculated by dividing its stock price of $2.74 by its TTM earnings per share of $0.27.
Frequently asked questions
SPRO pe ratio · 6 questionsSPRO's current PE ratio is 10.30x as of 2026-06-09, based on a stock price of $2.74 and TTM EPS of $0.27. Data sourced from Financial Modeling Prep via SPRO's SEC 10-K and 10-Q filings.
▸ Source: FMP · /ratios-ttm · /ratios annual · /analyst-estimates · /stock-peers · Spero Therapeutics, Inc. SEC 10-K & 10-Q filings · US GAAP · Updated: 2026-06-09