Tyra Biosciences, Inc.
Tyra Biosciences, Inc. (TYRA) Stock Ownership
Institutional vs insider vs public ownership from 13F and float data — top holders, activity, and insider trades below.
SEC 13F · FMP · TYRA · as of Sep 30, 2025
Ownership Breakdown
116
Institutional Holders
▼ 4 vs Q2
$778.40M
Total Inst. Value
▲ $236.89M vs Q2
59.47M
Shares Outstanding
freeFloat 74.30%
55.64M
13F Shares Held
▼ 950,019 vs Q2
Institutional ownership = 13F shares ÷ total outstanding. Insider % = 100 − free float. Public % = free float − institution %. Data: FMP /symbol-positions-summary + /shares-float + SEC EDGAR.
Top Institutional Holders
TYRA largest shareholders · institutional ownership
Q3 2025 · SEC 13F
Showing top 10 holders
| Holder | Shares | % Owned | Weight | Value | Reported | Change |
|---|---|---|---|---|---|---|
RA CAPITAL MANAGEMENT, L.P. pharmaceutical preparations | 12.20M | 20.48% | 20.48% | $170.66B | Nov 14, 2025 | — held |
ALTA PARTNERS MANAGEMENT COMPANY, L.P. pharmaceutical preparations | 4.08M | 6.85% | 6.85% | $57.08B | Nov 7, 2025 | — held |
NEXTECH INVEST, LTD. pharmaceutical preparations | 4.06M | 6.81% | 6.81% | $56.74B | Nov 14, 2025 | — held |
BVF INC/IL pharmaceutical preparations | 3.65M | 6.13% | 6.13% | $51.06B | Nov 14, 2025 | ▼ 294.4K |
CANAAN PARTNERS XI LLC pharmaceutical preparations | 3.61M | 6.06% | 6.06% | $50.48B | Oct 23, 2025 | — held |
COMMODORE CAPITAL LP pharmaceutical preparations | 3.38M | 5.67% | 5.67% | $47.22B | Nov 14, 2025 | ▲ 275.0K |
TCG CROSSOVER MANAGEMENT, LLC pharmaceutical preparations | 2.90M | 4.87% | 4.87% | $40.54B | Nov 17, 2025 | — held |
JANUS HENDERSON GROUP PLC pharmaceutical preparations | 2.87M | 4.83% | 4.83% | $40.23B | Nov 14, 2025 | ▲ 18.5K |
VESTAL POINT CAPITAL, LP pharmaceutical preparations | 2.42M | 4.07% | 4.07% | $33.93B | Nov 14, 2025 | ▼ 230.0K |
KYNAM CAPITAL MANAGEMENT, LP pharmaceutical preparations | 2.33M | 3.91% | 3.91% | $32.60B | Nov 14, 2025 | — held |
Data from SEC Form 13F filings. Ownership bar normalised to largest holder. Change flags: isNew / isSoldOut / changeInSharesNumber (FMP extract-analytics/holder).
Institutional Activity
Q3 2025 vs prior quarter
Q3 2025
21
Increased
+1.80M shares3
New Positions
first time holders15
Decreased
−1.79M shares0
Sold Out
fully exitedNet shares change (top 50)
+9.5K
+1.80M / −1.79M
Net new holders
+9
3 new / 0 exited
Based on top 50 institutional holders by position size. Fields: isNew, isSoldOut, changeInSharesNumber (FMP extract-analytics/holder, limit=50).
Insider Buying vs Selling
TYRA insider trading · insider activity
Source: SEC Form 4
11
Buy transactions
0
Sell transactions
0.00
Buy/Sell ratio
$0M
Total disposed
Recent Insider Transactions
Showing 10 most recent · Common Stock only
| Name · Role | Date | Type | Shares | Price | Value | After Trans. | Filing |
|---|---|---|---|---|---|---|---|
RA CAPITAL MANAGEMENT, L.P.
| May 28, 2026 | Award | 13,160 | $32.68 | $430.1K | 13.2K | Form 4 ↗ |
Verjee Rehan director | May 28, 2026 | Award | 13,160 | $32.68 | $430.1K | 13.2K | Form 4 ↗ |
Moran Susan director | May 28, 2026 | Award | 13,160 | $32.68 | $430.1K | 13.2K | Form 4 ↗ |
Simson Jake director | May 28, 2026 | Award | 13,160 | $32.68 | $430.1K | 13.2K | Form 4 ↗ |
Gulfo Adele M. director | May 28, 2026 | Award | 13,160 | $32.68 | $430.1K | 13.2K | Form 4 ↗ |
MORE ROBERT J director | May 28, 2026 | Award | 13,160 | $32.68 | $430.1K | 13.2K | Form 4 ↗ |
Rothenberg Stephen Michael director | May 28, 2026 | Award | 13,160 | $32.68 | $430.1K | 13.2K | Form 4 ↗ |
Warner Douglas J Chief Medical Officer | May 5, 2026 | Award | 85,000 | $33.93 | $2.88M | 85.0K | Form 4 ↗ |
Warner Douglas J Chief Medical Officer | May 5, 2026 | Award | 25,000 | — | — | 25.0K | Form 4 ↗ |
Fuhrman Alan Chief Financial Officer | May 5, 2026 | Award | 67,000 | $33.93 | $2.27M | 67.0K | Form 4 ↗ |
Source: /insider-trading/search (FMP stable). Buy/Sell direction: acquisitionOrDisposition A=Buy, D=Sell. RSU vesting (M-Exempt) excluded from sentiment bar. All data from SEC EDGAR public filings.
About institutional & insider ownership
Tyra Biosciences, Inc. (TYRA) is primarily owned by institutional investors, who hold approximately 93.6% of total shares outstanding. Company insiders own approximately 25.70%, while retail and public investors account for the remaining 0.00%.
The largest institutional shareholder of Tyra Biosciences, Inc. is RA CAPITAL MANAGEMENT, L.P., holding approximately 12.20 million shares — equal to 20.48% of outstanding shares — as of September 30, 2025.
A total of 116 institutional investors currently hold TYRA stock, with a combined institutional value of approximately $778,399,313 as of the most recent 13F filing period.
Frequently asked questions
TYRA ownershipTyra Biosciences, Inc. (TYRA) is primarily owned by institutional investors, who hold approximately 93.6% of shares. The largest shareholder is RA CAPITAL MANAGEMENT, L.P. with a 20.48% stake. Company insiders hold 25.70%. Data sourced from SEC Form 13F as of September 30, 2025.