Companies: 10,795·Total market cap: $144.5T
Denali Therapeutics Inc.

Denali Therapeutics Inc.

DNLINASDAQHealthcare● Active
$19.54
+$0.02(+0.10%)
Market Cap$3.1B
P/E Ratio
52W High$23.77
52W Low$12.58
Overview

Denali Therapeutics Inc. (DNLI) PE Ratio — Current & Historical Data

Trailing twelve months (TTM) P/E, forward P/E, PEG, and annual PE history — from market prices and filings.

dnli · pe ratio · data through Dec 31, 2025

Core PE Ratio Metrics

Trailing 12 months · TTM

The price-to-earnings (P/E) ratio for Denali Therapeutics Inc. (DNLI) measures how much investors pay for each dollar of the company's trailing earnings. DNLI's current PE ratio of N/A is calculated by dividing its stock price of $19.54 by its TTM earnings per share of -$2.72.

N/A
P/E Ratio (TTM)N/A — Company is not profitable (TTM)

Source: FMP · /ratios-ttm · /analyst-estimates · 2025-12-31

Forward P/E
N/A
FY2027 est. EPS $-2.43
Based on 14 analysts
EPS (TTM)
-$2.72
TTM · diluted EPS
PEG Ratio
0.92
Below 1.0 · Growth adjusted
Source: FMP · /ratios-ttm · /ratios annual · /analyst-estimates · /stock-peers · Denali Therapeutics Inc. SEC 10-K & 10-Q filings · US GAAPUpdated: 2026-06-08

PE Ratio History

2015 – 2025 · Annual
PE Ratio (TTM)
5Y Avg 128.3x
EPS (Annual)

▸ FMP /ratios?period=annual&limit=20 · priceToEarningsRatio + netIncomePerShare (Annual)

PE Ratio vs Peers

Biotechnology · 6 peers · Annual PE
CompanyMarket CapPE (Annual)vs AvgEPS (TTM)
Denali Therapeutics Inc.
Denali Therapeutics Inc.You
DNLI
$3.1BN/A-$2.72
Agios Pharmaceuticals, Inc.
Agios Pharmaceuticals, Inc.
AGIO
$1.6BN/A-$7.12
Beam Therapeutics Inc.
Beam Therapeutics Inc.
BEAM
$3.1BN/A-$0.81
Cogent Biosciences, Inc.
Cogent Biosciences, Inc.
COGT
$5.3BN/A-$4.87
89bio, Inc.
89bio, Inc.
ETNB
$2.2BN/A-$3.51
Galapagos N.V.
Galapagos N.V.
GLPG
$1.8B5.74x$4.85
ImmunityBio, Inc.
ImmunityBio, Inc.
IBRX
$7.5BN/A-$0.38

* N/A — Company is not profitable (TTM) · excluded from industry average · ▸ FMP /stock-peers + /ratios?limit=1 · priceToEarningsRatio

Annual PE Ratio History

Showing 10 of 11 years
Fiscal Year EndPE RatioEPS (TTM)YoY ChangePE vs Max
2025-12-31Latest
FY2025
$-2.92
2024-12-31
FY2024
$-2.57
2023-12-31
FY2023
$-1.06
2022-12-31
FY2022
$-2.60
2021-12-31
FY2021
$-2.39
2020-12-31
FY2020
128.31x$0.65
2019-12-31
FY2019
$-2.07
2018-12-31
FY2018
$-0.39
2017-12-31
FY2017
$-5.89
2016-12-31
FY2016
$-13.49

▸ FMP /ratios?period=annual&limit=20 · priceToEarningsRatio + netIncomePerShare · Zero extra API

About PE Ratio & Methodology

The price-to-earnings (P/E) ratio for Denali Therapeutics Inc. (DNLI) measures how much investors pay for each dollar of the company's trailing earnings. DNLI's current PE ratio of N/A is calculated by dividing its stock price of $19.54 by its TTM earnings per share of -$2.72.

PE Ratio = Stock Price ÷ EPS (TTM)
= $19.54 ÷ -$2.72 = N/A
TTMTrailing Twelve Months — sum of the most recent 4 quarterly EPS figures
Forward PEStock price ÷ analyst consensus EPS estimate for the next fiscal year
PEGPE ÷ earnings growth rate — values below 1.0 suggest growth may justify the premium
Figures tie to SEC 10-K/10-Q and FMP ratio endpoints where noted.

Frequently asked questions

DNLI pe ratio · 6 questions

DNLI's current PE ratio is N/A as of 2026-06-08, based on a stock price of $19.54 and TTM EPS of -$2.72. Data sourced from Financial Modeling Prep via DNLI's SEC 10-K and 10-Q filings.

DNLI PE ratioWhat is DNLI PE ratioCurrent PE ratio of DNLIDNLI PE ratio today

Source: FMP · /ratios-ttm · /ratios annual · /analyst-estimates · /stock-peers · Denali Therapeutics Inc. SEC 10-K & 10-Q filings · US GAAP · Updated: 2026-06-08