Ionis Pharmaceuticals, Inc.

IONSNASDAQHealthcare● Active

$73.87

$-0.62(-0.83%)

Market Cap$12.2B

P/E Ratio—

52W High$86.74

52W Low$34.78

Avg Volume1.9M

Open$74.34

Beta0.37

Overview

Ionis Pharmaceuticals, Inc. (IONS) Net Income & Profit History

Annual & trailing net income, net margin, YoY change, and peer profitability context.

IONS · net income · updated Jun 8, 2026

Core profitability metrics

IONS · net income · margin · TTM · CAGR

Net income was −$381.0M for FY2025 (fiscal year ending 2025-12-31), up 16.1% year-over-year. Net profit margin was -40.4%. Based on available data, Ionis Pharmaceuticals, Inc. has been profitable since at least 2017.

FY2025 Net Income−$381.0M▲ +16.1% YoY

Trailing 12M (TTM)−$326.6Mtrailing 4 quarters sum

Net Profit Margin-40.4%−$381.0M ÷ $944.0M

YoY Change+16.1%—

5-Year CAGRN/AN/A — contains loss years

FormulaNet Margin = Net Income ÷ Revenue × 100TTM = trailing 4 quarters sumCAGR → N/A if either endpoint ≤ 0

Source: FMP /income-statement · US GAAP · USDUpdated: Jun 8, 2026

Annual net income history

Net Income (bars) · Net Profit Margin % (line)

Net IncomeNet LossNet Margin %★ First Profit: 2017

▸ FMP /income-statement · Annual · IONS net income history · IONS profit margin

Annual net income data

IONS · net income history · annual / quarterly

Fiscal YearNet IncomeYoY ChangeNet MarginRevenue

FY2025Loss−$381.0M▲ +16.1%-40.4%$944.0M

FY2024Loss−$453.9M▼ 23.9%-64.4%$705.1M

FY2023Loss−$366.3M▼ 35.8%-46.5%$787.6M

FY2022Loss−$269.7M▼ 843.2%-45.9%$587.4M

FY2021Loss−$28.6M▲ +93.6%-3.5%$810.5M

Net income vs peers (Healthcare)

IONS vs peers · net income

#CompanyNet IncomeYoYNet MarginRelative

Ionis Pharmaceuticals, Inc.YOU

IONS

−$381.0M+16.1%-40.4%

Loss

Eli Lilly and Company

LLY

$20.64B+94.9%31.7%

77%

UnitedHealth Group Incorporated

Healthcare · Sorted by Net Income · FMP /income-statementFull Net Income Rankings →

About Net Income & Methodology

Ionis Pharmaceuticals, Inc. (IONS) reported net income of −$381.0M for FY2025 (fiscal year ending 2025-12-31), up 16.1% year-over-year. The net profit margin was -40.4% — meaning the company kept $-0.40 of every dollar of revenue as profit.

Based on available data, Ionis Pharmaceuticals, Inc. has been profitable since at least 2017. Net income reached a peak of $278.1M in FY2019. Data available for 15 fiscal years.

Ionis Pharmaceuticals, Inc.'s net profit margin was -40.4% for FY2025, based on the latest annual results.

Investors sometimes search for "Ionis Pharmaceuticals, Inc. net worth" — the company's market capitalization is a separate figure from IONS net income. Data sourced from FMP /income-statement · US GAAP · USD.

Figures tie to SEC 10-K/10-Q and FMP /income-statement where noted.

Revenue Financial statements Earnings Forecast Price history Market cap Free cash flow

Frequently asked questions

IONS net income · 4 questions

Ionis Pharmaceuticals, Inc. is not currently profitable on an annual basis. The company reported a net loss of $381.0M for FY2025.

is IONS profitabledoes IONS make a profitIONS profitabilityIONS profitable company

▸ Source: FMP /income-statement · GAAP · Ionis Pharmaceuticals, Inc. · Ionis Pharmaceuticals, Inc. SEC 10-K & 10-Q filings · US GAAP · Last updated: Jun 8, 2026