Companies: 10,795·Total market cap: $144.5T
Septerna, Inc.

Septerna, Inc.

SEPNNASDAQHealthcare● Active
$30.42
$-0.74(-2.36%)
Market Cap$1.4B
P/E Ratio
52W High$32.63
52W Low$9.7

Septerna, Inc. (SEPN) Stock Forecast & Analyst Price Target

Wall Street consensus, 12-month price targets, model projections, and EPS/revenue estimates — from analyst data and price history.

sepn · stock forecast · 6 analysts (3M) · FMP · updated Jun 8, 2026

Analyst Rating & Consensus

Based on 6 Wall Street analysts in the past 3 months

SellBuy

Buy

6 analysts

consensus

Rating Breakdown

Strong Buy
0
Buy
6
Hold
0
Sell
0
Strong Sell
0
Total: 6 · Buy rate: 100.0%

12-Month Price Target

High

$60.00

Consensus

$45.50

+46.9% upside

Low

$34.00

Median: $44 · Last Close: $30.97

The Septerna, Inc. (SEPN) analyst consensus is Buy, based on ratings from 6 Wall Street analysts over the past 3 months. The average 12-month SEPN price target is $45.50, representing +46.9% upside from the current price of $30.97.

12-Month Price Target Forecast

Historical closing prices + analyst 12-month price target forecast cone

Historical priceConsensus $46 (46.9%)

Consensus Target

$45.50

46.9% upside

High Target

$60

93.7%

Low Target

$34

9.8%

Current Price

$30.97

as of today

Based on analyst price targets, the SEPN stock price prediction for the next 12 months ranges from $34 to $60. The consensus SEPN price forecast of $45.50 implies 46.9% upside from the current price of $30.97.

Short-Term Price Prediction

Bull

Algorithmically generated · Updated daily

DatePredicted PriceChange
2026-06-09$32.525.00%

1-day model range: $32.27–$32.76. Peak: $32.76 (+5.00%).

Long-Term Stock Price Prediction

Annual stock price forecast · 2027 / 2028 / 2029 / 2030 / 2031

YearAvg PriceChange
2027$68+120.0%
2028$113+265.2%
2029$154+397.8%
2030$185+497.1%
2031+562.7%
Confidence:MediumCapped at 120% annual limit

Stock Forecast Based on Technical Analysis

14 TA signals (SMA×6 + EMA×6 + RSI + MACD) · EEAT method transparency

Market Sentiment

BULLISH

Based on 14 technical indicators

93%0%7%
13Buy
0Neutral
1Sell
RSI (14)74.3Overbought
MACDBULLISH

Refreshes daily from EOD close

Moving Averages · SEPN · Jun 8, 2026

Simple Moving Average (SMA)
MA 5$30.80BUY
MA 10$30.56BUY
MA 20$28.56BUY
MA 50$26.17BUY
MA 100$26.32BUY
MA 200$23.89BUY
Current $SEPN · Price above MA = BUY signal
Exponential Moving Average (EMA)
EMA 5$30.82BUY
EMA 10$30.20BUY
EMA 20$28.95BUY
EMA 50$27.23BUY
EMA 100$26.04BUY
EMA 200$22.65BUY
Current $SEPN · Price above MA = BUY signal
How we calculate: Technical sentiment is derived from 14 indicators — SMA(5,10,20,50,100,200), EMA(5,10,20,50,100,200), RSI(14), and MACD(12,26,9) — calculated from historical EOD price data. BUY = current price above MA; SELL = below. 14 TA signals + historical EOD price data · Updated daily. Independent of analyst consensus data. Not investment advice.

Latest Analyst Ratings & Upgrades

Filter:
HC Wainwright & Co.2026-05-13
Maintains
BuyBuy
HC Wainwright & Co.2026-04-14
Maintains
BuyBuy
JP Morgan2026-03-24
Maintains
OverweightOverweight
Truist Securities2026-03-11
Maintains
BuyBuy
Wells Fargo2026-03-03
Maintains
OverweightOverweight
HC Wainwright & Co.2026-03-02
Maintains
BuyBuy
HC Wainwright& Co.2026-03-02
Maintains
BuyBuy
HC Wainwright & Co.2026-01-20
Maintains
BuyBuy
Wells Fargo2025-11-14
Upgrade ↑
Equal WeightOverweight
HC Wainwright & Co.2025-11-11
Maintains
BuyBuy

Wall Street analysts have recently issued updated ratings on Septerna, Inc. (SEPN) stock. Of the recent 17 rating actions, 1 were upgrades and 1 were downgrades. 6 analysts currently cover SEPN.

Analyst Recommendation Trends

Buy ratings11
Hold ratings00
Sell ratings00

SEPN analyst recommendation trends show stable buy-side sentiment over the past 6 months. Buy rating actions changed from 1 to 1 per month.

Financial Forecast: EPS & Revenue Estimates

Revenue This Year

$74M

↑ 10.4% YoY

Revenue Next Year

$62M

↓ 16.6% YoY

EPS This Year

$-1.68

EPS Next Year

$-2.41

↑ 43.7% YoY

EPS ForecastReported vs Estimated

Reported EPSHistorical estimateAnalyst forecast (future)

Analysts forecast SEPN EPS of $-1.68 for the current fiscal year, based on estimates from 6 analysts. The SEPN revenue forecast is $74M for the current year. These are analyst consensus estimates via FMP / S&P Global.

About Forecast & Price Prediction

The SEPN stock forecast is supported by two independent data sources: analyst consensus ratings from 6 Wall Street analysts (S&P Global / FMP), and technical analysis calculated from historical EOD price data. The consensus SEPN price target is $45.50 (+46.9% upside), with an analyst consensus of Buy.

The SEPN short-term stock prediction for tomorrow is $32.52 (+5.00%). The SEPN stock price prediction for 2027 estimates an average of $68. The SEPN stock prediction for 2030 projects a range of $170–$200.

Septerna, Inc. trades on NASDAQ under the ticker SEPN. The SEPN stock outlook for 2027 is broadly positive, supported by a Buy consensus among 100% of covering analysts.

FAQ answers synthesize analyst targets, estimates, and on-page model outputs where shown.

Frequently asked questions

SEPN forecast · 8 questions

According to 6 Wall Street analysts, the average 12-month SEPN price target is $45.50, with a high forecast of $60.00 and a low of $34.00. The median price target is shown in the chart above when available. This implies +46.9% potential upside from the current price of $30.97.

SEPN price targetWhat is SEPN price targetSEPN analyst price targetSEPN 12-month target

· Analyst data: Financial Modeling Prep (FMP) · S&P Global Market Intelligence · Technical analysis: FMP /historical-price-eod/light · Updated: Hourly (analyst) · Daily (technical)

⚠ This information is provided for informational purposes only and does not constitute investment advice. Short-term and long-term price predictions are algorithmically generated and carry significant uncertainty. Past performance does not guarantee future results. Always conduct your own due diligence before making investment decisions.