Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. (IONS) PE Ratio — Current & Historical Data
Trailing twelve months (TTM) P/E, forward P/E, PEG, and annual PE history — from market prices and filings.
ions · pe ratio · data through Dec 31, 2025
Core PE Ratio Metrics
Trailing 12 months · TTMThe price-to-earnings (P/E) ratio for Ionis Pharmaceuticals, Inc. (IONS) measures how much investors pay for each dollar of the company's trailing earnings. IONS's current PE ratio of N/A is calculated by dividing its stock price of $74.48 by its TTM earnings per share of -$1.98.
Source: FMP · /ratios-ttm · /analyst-estimates · 2025-12-31
PE Ratio History
2006 – 2025 · Annual▸ FMP /ratios?period=annual&limit=20 · priceToEarningsRatio + netIncomePerShare (Annual)
Historical PE Range
Past 3 fiscal years · Front-end computedMinQ1 · 25%26.1x
MedianQ3 · 75%30.4x
Max
At N/A, IONS's current P/E is lower than in 0% of its annual fiscal year readings over the past 3 years — historically low.
Percentile calculated from annual fiscal year data points, not by trading day. Years where PE ≤ 0 or > 9,999 are excluded.
PE Ratio vs Peers
Biotechnology · 6 peers · Annual PE| Company | Market Cap | PE (Annual) | vs Avg | EPS (TTM) |
|---|---|---|---|---|
Ionis Pharmaceuticals, Inc.You IONS | $12.3B | N/A | — | -$1.98 |
 Ascendis Pharma A/S ASND | $13.0B | N/A | — | -$3.61 |
 BridgeBio Pharma, Inc. BBIO | $13.2B | N/A | — | -$3.70 |
 BioMarin Pharmaceutical Inc. BMRN | $11.0B | 32.67x | +36.7% | $1.82 |
 Exelixis, Inc. EXEL | $13.2B | 15.12x | -36.7% | $2.88 |
 Guardant Health, Inc. GH | $16.7B | N/A | — | -$3.32 |
 Madrigal Pharmaceuticals, Inc. MDGL | $11.2B | N/A | — | -$12.85 |
Industry Average 2 peers with valid PE | — | 23.90x | baseline | — |
* N/A — Company is not profitable (TTM) · excluded from industry average · ▸ FMP /stock-peers + /ratios?limit=1 · priceToEarningsRatio
Annual PE Ratio History
| Fiscal Year End | PE Ratio | EPS (TTM) | YoY Change | PE vs Max |
|---|---|---|---|---|
2025-12-31Latest FY2025 | — | $-2.38 | — | |
2024-12-31 FY2024 | — | $-3.04 | — | |
2023-12-31 FY2023 | — | $-2.56 | — | |
2022-12-31 FY2022 | — | $-1.90 | — | |
2021-12-31 FY2021 | — | $-0.20 | — | |
2020-12-31 FY2020 | — | $-3.18 | — | |
2019-12-31 FY2019 | 30.41x | $1.99 | +16.4% | |
2018-12-31 FY2018 | 26.13x | $2.07 | -99.9% | |
2017-12-31 FY2017 | — | $0.00 | — | |
2016-12-31 FY2016 | — | $-0.50 | — |
▸ FMP /ratios?period=annual&limit=20 · priceToEarningsRatio + netIncomePerShare · Zero extra API
About PE Ratio & Methodology
The price-to-earnings (P/E) ratio for Ionis Pharmaceuticals, Inc. (IONS) measures how much investors pay for each dollar of the company's trailing earnings. IONS's current PE ratio of N/A is calculated by dividing its stock price of $74.48 by its TTM earnings per share of -$1.98.
Frequently asked questions
IONS pe ratio · 6 questionsIONS's current PE ratio is N/A as of 2026-06-08, based on a stock price of $74.48 and TTM EPS of -$1.98. Data sourced from Financial Modeling Prep via IONS's SEC 10-K and 10-Q filings.
▸ Source: FMP · /ratios-ttm · /ratios annual · /analyst-estimates · /stock-peers · Ionis Pharmaceuticals, Inc. SEC 10-K & 10-Q filings · US GAAP · Updated: 2026-06-08