Milestone Pharmaceuticals Inc.
Milestone Pharmaceuticals Inc. (MIST) Stock Ownership
Institutional vs insider vs public ownership from 13F and float data — top holders, activity, and insider trades below.
SEC 13F · FMP · MIST · as of Sep 30, 2025
Ownership Breakdown
67
Institutional Holders
▲ 18 vs Q2
$68.28M
Total Inst. Value
▲ $45.34M vs Q2
85.89M
Shares Outstanding
freeFloat 98.64%
34.14M
13F Shares Held
▲ 22.31M vs Q2
Institutional ownership = 13F shares ÷ total outstanding. Insider % = 100 − free float. Public % = free float − institution %. Data: FMP /symbol-positions-summary + /shares-float + SEC EDGAR.
Top Institutional Holders
MIST largest shareholders · institutional ownership
Q3 2025 · SEC 13F
Showing top 10 holders
| Holder | Shares | % Owned | Weight | Value | Reported | Change |
|---|---|---|---|---|---|---|
ADAGE CAPITAL PARTNERS GP, L.L.C. pharmaceutical preparations | 6.98M | 10.51% | 10.51% | $13.95B | Nov 14, 2025 | NEW |
PROPEL BIO MANAGEMENT, LLC pharmaceutical preparations | 5.12M | 7.72% | 7.72% | $10.25B | Nov 12, 2025 | ▲ 3.33M |
ORBIMED ADVISORS LLC pharmaceutical preparations | 3.22M | 4.85% | 4.85% | $6.44B | Nov 14, 2025 | NEW |
MORGAN STANLEY pharmaceutical preparations | 2.97M | 4.47% | 4.47% | $5.94B | May 27, 2026 | ▲ 2.15M |
SIMPLIFY ASSET MANAGEMENT INC. pharmaceutical preparations | 2.83M | 4.27% | 4.27% | $5.67B | Oct 20, 2025 | ▲ 1.84M |
RTW INVESTMENTS, LP pharmaceutical preparations | 2.51M | 3.78% | 3.78% | $5.01B | Nov 14, 2025 | — held |
PATHSTONE HOLDINGS, LLC pharmaceutical preparations | 1.00M | 1.51% | 1.51% | $2.00B | Nov 13, 2025 | NEW |
SPHERA FUNDS MANAGEMENT LTD. pharmaceutical preparations | 820.0K | 1.24% | 1.24% | $1.64B | Nov 14, 2025 | NEW |
TORONTO DOMINION BANK pharmaceutical preparations | 750.0K | 1.13% | 1.13% | $1.50B | Nov 14, 2025 | — held |
AFFINITY ASSET ADVISORS, LLC pharmaceutical preparations | 666.7K | 1.00% | 1.00% | $1.33B | Nov 13, 2025 | NEW |
Data from SEC Form 13F filings. Ownership bar normalised to largest holder. Change flags: isNew / isSoldOut / changeInSharesNumber (FMP extract-analytics/holder).
Institutional Activity
Q3 2025 vs prior quarter
Q3 2025
24
Increased
+9.63M shares16
New Positions
first time holders3
Decreased
−42.3K shares0
Sold Out
fully exitedNet shares change (top 50)
+9.59M
+9.63M / −42.3K
Net new holders
+37
16 new / 0 exited
Based on top 50 institutional holders by position size. Fields: isNew, isSoldOut, changeInSharesNumber (FMP extract-analytics/holder, limit=50).
Insider Buying vs Selling
MIST insider trading · insider activity
Source: SEC Form 4
Insiders have been primarily selling shares recently. Selling may be driven by pre-scheduled Rule 10b5-1 plans rather than negative sentiment.
15
Buy transactions
12
Sell transactions
1.25
Buy/Sell ratio
$0M
Total disposed
Recent Insider Transactions
Showing 10 most recent · Common Stock only
| Name · Role | Date | Type | Shares | Price | Value | After Trans. | Filing |
|---|---|---|---|---|---|---|---|
Oliveto Joseph President and CEO | Apr 16, 2026 | Sale | 36,500 | $2.26 | $82.5K | 446.2K | Form 4 ↗ |
Oliveto Joseph President and CEO | Feb 2, 2026 | Award | 679,000 | $1.96 | $1.33M | 679.0K | Form 4 ↗ |
Bharucha David Chief Medical Officer | Feb 2, 2026 | Award | 204,000 | $1.96 | $399.8K | 204.0K | Form 4 ↗ |
Nelson Jeffrey Edward Chief Operating Officer | Feb 2, 2026 | Award | 204,000 | $1.96 | $399.8K | 204.0K | Form 4 ↗ |
Muller Lorenz Chief Commercial Officer | Feb 2, 2026 | Award | 204,000 | $1.96 | $399.8K | 204.0K | Form 4 ↗ |
Hasija Amit CFO & EVP of Corp. Development | Feb 2, 2026 | Award | 204,000 | $1.96 | $399.8K | 204.0K | Form 4 ↗ |
Muller Lorenz Chief Commercial Officer | Feb 2, 2026 | Award | 204,000 | $1.97 | $401.9K | 204.0K | Form 4 ↗ |
Hasija Amit CFO & EVP of Corp. Development | Feb 2, 2026 | Award | 204,000 | $1.97 | $401.9K | 204.0K | Form 4 ↗ |
Nelson Jeffrey Edward Chief Operating Officer | Feb 2, 2026 | Award | 204,000 | $1.97 | $401.9K | 204.0K | Form 4 ↗ |
Bharucha David Chief Medical Officer | Feb 2, 2026 | Award | 204,000 | $1.97 | $401.9K | 204.0K | Form 4 ↗ |
Source: /insider-trading/search (FMP stable). Buy/Sell direction: acquisitionOrDisposition A=Buy, D=Sell. RSU vesting (M-Exempt) excluded from sentiment bar. All data from SEC EDGAR public filings.
About institutional & insider ownership
Milestone Pharmaceuticals Inc. (MIST) is primarily owned by institutional investors, who hold approximately 39.8% of total shares outstanding. Company insiders own approximately 1.36%, while retail and public investors account for the remaining 58.89%.
The largest institutional shareholder of Milestone Pharmaceuticals Inc. is ADAGE CAPITAL PARTNERS GP, L.L.C., holding approximately 6.98 million shares — equal to 10.51% of outstanding shares — as of September 30, 2025.
A total of 67 institutional investors currently hold MIST stock, with a combined institutional value of approximately $68,276,904 as of the most recent 13F filing period.
Frequently asked questions
MIST ownershipMilestone Pharmaceuticals Inc. (MIST) is primarily owned by institutional investors, who hold approximately 39.8% of shares. The largest shareholder is ADAGE CAPITAL PARTNERS GP, L.L.C. with a 10.51% stake. Company insiders hold 1.36%. Data sourced from SEC Form 13F as of September 30, 2025.