OPKO Health, Inc.
OPKO Health, Inc. (OPK) Stock Ownership
Institutional vs insider vs public ownership from 13F and float data — top holders, activity, and insider trades below.
SEC 13F · FMP · OPK · as of Sep 30, 2025
Ownership Breakdown
242
Institutional Holders
▲ 15 vs Q2
$303.61M
Total Inst. Value
▲ $33.19M vs Q2
755.09M
Shares Outstanding
freeFloat 44.06%
196.33M
13F Shares Held
▼ 8.86M vs Q2
Institutional ownership = 13F shares ÷ total outstanding. Insider % = 100 − free float. Public % = free float − institution %. Data: FMP /symbol-positions-summary + /shares-float + SEC EDGAR.
Top Institutional Holders
OPK largest shareholders · institutional ownership
Q3 2025 · SEC 13F
Showing top 10 holders
| Holder | Shares | % Owned | Weight | Value | Reported | Change |
|---|---|---|---|---|---|---|
RUBRIC CAPITAL MANAGEMENT LP pharmaceutical preparations | 47.79M | 7.12% | 7.12% | $74.08B | Nov 14, 2025 | — held |
VANGUARD GROUP INC pharmaceutical preparations | 37.54M | 5.59% | 5.59% | $58.18B | Nov 7, 2025 | ▼ 702.8K |
BLACKROCK, INC. pharmaceutical preparations | 33.17M | 4.94% | 4.94% | $51.42B | Nov 12, 2025 | ▲ 1.72M |
GEODE CAPITAL MANAGEMENT, LLC pharmaceutical preparations | 10.99M | 1.64% | 1.64% | $17.04B | Nov 12, 2025 | ▲ 568.9K |
STATE STREET CORP pharmaceutical preparations | 9.00M | 1.34% | 1.34% | $13.95B | Nov 14, 2025 | ▲ 416.1K |
WHITEFORT CAPITAL MANAGEMENT, LP pharmaceutical preparations | 4.90M | 72.96% | 72.96% | $7.59B | Nov 14, 2025 | ▲ 3.13M |
UBS GROUP AG pharmaceutical preparations | 4.78M | 71.11% | 71.11% | $7.40B | Nov 13, 2025 | ▼ 944.1K |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC pharmaceutical preparations | 3.77M | 56.12% | 56.12% | $5.84B | Nov 10, 2025 | ▲ 418.6K |
NORTHERN TRUST CORP pharmaceutical preparations | 3.66M | 54.47% | 54.47% | $5.67B | Nov 14, 2025 | ▲ 175.6K |
AQR CAPITAL MANAGEMENT LLC pharmaceutical preparations | 2.87M | 42.79% | 42.79% | $4.45B | Nov 14, 2025 | ▲ 1.94M |
Data from SEC Form 13F filings. Ownership bar normalised to largest holder. Change flags: isNew / isSoldOut / changeInSharesNumber (FMP extract-analytics/holder).
Institutional Activity
Q3 2025 vs prior quarter
Q3 2025
23
Increased
+9.67M shares1
New Positions
first time holders22
Decreased
−12.24M shares0
Sold Out
fully exitedNet shares change (top 50)
2.57M
+9.67M / −12.24M
Net new holders
+2
1 new / 0 exited
Based on top 50 institutional holders by position size. Fields: isNew, isSoldOut, changeInSharesNumber (FMP extract-analytics/holder, limit=50).
Insider Buying vs Selling
OPK insider trading · insider activity
Source: SEC Form 4
Insiders have been net buyers of shares recently. Selling may be driven by pre-scheduled Rule 10b5-1 plans rather than negative sentiment.
2
Buy transactions
0
Sell transactions
0.00
Buy/Sell ratio
$0M
Total disposed
Recent Insider Transactions
Showing 10 most recent · Common Stock only
| Name · Role | Date | Type | Shares | Price | Value | After Trans. | Filing |
|---|---|---|---|---|---|---|---|
PAGANELLI JOHN A director | Mar 20, 2026 | Purchase | 10,000 | $1.14 | $11.3K | 394.3K | Form 4 ↗ |
UPPALURI SUBBARAO V director | Mar 18, 2026 | Award | 50,000 | $1.17 | $58.5K | 50.0K | Form 4 ↗ |
FROST PHILLIP MD ET AL CEO & Chairman | Nov 21, 2025 | Purchase | 192,870 | $1.33 | $257.5K | 216.71M | Form 4 ↗ |
FROST PHILLIP MD ET AL CEO & Chairman | Nov 21, 2025 | Purchase | 191,490 | $1.33 | $254.7K | 216.51M | Form 4 ↗ |
FROST PHILLIP MD ET AL CEO & Chairman | Nov 21, 2025 | Purchase | 89,375 | $1.32 | $118.4K | 216.32M | Form 4 ↗ |
FROST PHILLIP MD ET AL CEO & Chairman | Nov 21, 2025 | Purchase | 3,894 | $1.32 | $5.1K | 216.23M | Form 4 ↗ |
FROST PHILLIP MD ET AL CEO & Chairman | Nov 21, 2025 | Purchase | 102,371 | $1.30 | $133.1K | 216.23M | Form 4 ↗ |
FROST PHILLIP MD ET AL CEO & Chairman | Nov 20, 2025 | Purchase | 13,664 | $1.35 | $18.4K | 216.13M | Form 4 ↗ |
FROST PHILLIP MD ET AL CEO & Chairman | Nov 20, 2025 | Purchase | 1,757 | $1.34 | $2.4K | 216.11M | Form 4 ↗ |
FROST PHILLIP MD ET AL CEO & Chairman | Nov 20, 2025 | Purchase | 24,579 | $1.34 | $32.9K | 216.11M | Form 4 ↗ |
Source: /insider-trading/search (FMP stable). Buy/Sell direction: acquisitionOrDisposition A=Buy, D=Sell. RSU vesting (M-Exempt) excluded from sentiment bar. All data from SEC EDGAR public filings.
About institutional & insider ownership
OPKO Health, Inc. (OPK) is primarily owned by institutional investors, who hold approximately 26.0% of total shares outstanding. Company insiders own approximately 55.94%, while retail and public investors account for the remaining 18.06%.
The largest institutional shareholder of OPKO Health, Inc. is RUBRIC CAPITAL MANAGEMENT LP, holding approximately 47.79 million shares — equal to 7.12% of outstanding shares — as of September 30, 2025.
A total of 242 institutional investors currently hold OPK stock, with a combined institutional value of approximately $303,607,258 as of the most recent 13F filing period.
Frequently asked questions
OPK ownershipOPKO Health, Inc. (OPK) is primarily owned by institutional investors, who hold approximately 26.0% of shares. The largest shareholder is RUBRIC CAPITAL MANAGEMENT LP with a 7.12% stake. Company insiders hold 55.94%. Data sourced from SEC Form 13F as of September 30, 2025.