Companies: 10,795·Total market cap: $144.5T
Sionna Therapeutics, Inc.

Sionna Therapeutics, Inc.

SIONNASDAQHealthcare● Active
$33.26
$-2.11(-5.95%)
Market Cap$1.5B
P/E Ratio
52W High$48.445
52W Low$13.51

Sionna Therapeutics, Inc. (SION) Insider Trading

Form 4 buy vs sell counts, ratio, and sentiment — switch this quarter or last 12 months; chart and transactions below.

SEC EDGAR · FMP · SION · as of Jun 8, 2026

Activity summary

Buy transactions

0

P-Purchase only

Sell transactions

153

12 Months

Buy/Sell ratio

0.00

Buy/Sell (by trades)

Overall sentiment

BEARISH
↑ Buy 0%Active transactions only · RSU vesting excluded100% Sell ↓

Sionna Therapeutics, Inc. insiders have been primarily selling shares over the past 12 Months. Selling activity is often driven by pre-scheduled Rule 10b5-1 plans rather than negative sentiment toward the company.

Source: SEC EDGAR · Form 3 & 4 · via Financial Modeling Prep · Buy = P-Purchase only · Sell = S-Sale only

As of Jun 8, 2026

SION insider buying and selling by quarter

SION insider selling · SION insider buying stocks · quarterly insider activity

Total insider buying (incl. awards)Total insider selling
1.7M859K0
2025 Q3
2025 Q4
2026 Q1
2026 Q2

Mobile shows last 4Q · Desktop shows full 8Q

Source: SEC EDGAR · Form 3 & 4 · via Financial Modeling Prep · last 8 quarters

As of Jun 8, 2026

Active insiders

Most active in past 12 months · SION ceo insider trading

Showing all insiders · Click a card to filter the transactions table below

Aggregated from reportingName · top 5 by trade count (12M) · no extra API

Recent insider transactions

SION executive sell shares · SION board member insider trading · SION insider trading SEC filing

Showing 93 most recent · Common Stock · Form 4 only

Scroll horizontally to see all columns

Thompson Peter A.

Director

Sale

Date

May 27

Shares

101

Price

$44.49

Value

$4K

View Form 4 on SEC.gov

ORBIMED ADVISORS LLC

Director

Sale

Date

May 27

Shares

101

Price

$44.49

Value

$4K

View Form 4 on SEC.gov

Thompson Peter A.

Director

Sale

Date

May 7

Shares

48,546

Price

$44.61

Value

$2.17M ⚡

View Form 4 on SEC.gov

Thompson Peter A.

Director

Sale

Date

May 8

Shares

59,767

Price

$44.58

Value

$2.66M ⚡

View Form 4 on SEC.gov

Thompson Peter A.

Director

Sale

Date

May 11

Shares

184,639

Price

$46.22

Value

$8.53M ⚡

View Form 4 on SEC.gov

ORBIMED ADVISORS LLC

Director

Sale

Date

May 7

Shares

48,546

Price

$44.61

Value

$2.17M ⚡

View Form 4 on SEC.gov

ORBIMED ADVISORS LLC

Director

Sale

Date

May 8

Shares

59,767

Price

$44.58

Value

$2.66M ⚡

View Form 4 on SEC.gov

ORBIMED ADVISORS LLC

Director

Sale

Date

May 11

Shares

184,639

Price

$46.22

Value

$8.53M ⚡

View Form 4 on SEC.gov

Thompson Peter A.

Director

Sale

Date

Apr 17

Shares

52,397

Price

$44.68

Value

$2.34M ⚡

View Form 4 on SEC.gov

Thompson Peter A.

Director

Sale

Date

Apr 18

Shares

2,948

Price

$44.52

Value

$131K

View Form 4 on SEC.gov

ORBIMED ADVISORS LLC

Director

Sale

Date

Apr 17

Shares

52,397

Price

$44.68

Value

$2.34M ⚡

View Form 4 on SEC.gov

ORBIMED ADVISORS LLC

Director

Sale

Date

Apr 18

Shares

2,948

Price

$44.52

Value

$131K

View Form 4 on SEC.gov

Thompson Peter A.

Director

Sale

Date

Apr 14

Shares

47,814

Price

$44.51

Value

$2.13M ⚡

View Form 4 on SEC.gov

Thompson Peter A.

Director

Sale

Date

Apr 15

Shares

235,863

Price

$44.64

Value

$10.53M ⚡

View Form 4 on SEC.gov

Thompson Peter A.

Director

Sale

Date

Apr 16

Shares

226,906

Price

$45.34

Value

$10.29M ⚡

View Form 4 on SEC.gov

ORBIMED ADVISORS LLC

Director

Sale

Date

Apr 14

Shares

47,814

Price

$44.51

Value

$2.13M ⚡

View Form 4 on SEC.gov

ORBIMED ADVISORS LLC

Director

Sale

Date

Apr 15

Shares

235,863

Price

$44.64

Value

$10.53M ⚡

View Form 4 on SEC.gov

ORBIMED ADVISORS LLC

Director

Sale

Date

Apr 16

Shares

226,906

Price

$45.34

Value

$10.29M ⚡

View Form 4 on SEC.gov

Fitzpatrick Jennifer

Chief Legal Officer

Option

Date

Mar 5

Shares

10,250

Price

$6.11

Value

$63K

View Form 4 on SEC.gov

Fitzpatrick Jennifer

Chief Legal Officer

Sale

Date

Mar 5

Shares

10,250

Price

$33.86

Value

$347K

View Form 4 on SEC.gov

Thompson Peter A.

Director

Sale

Date

Feb 2

Shares

1,890

Price

$44.57

Value

$84K

View Form 4 on SEC.gov

Thompson Peter A.

Director

Sale

Date

Feb 3

Shares

29,063

Price

$44.58

Value

$1.30M ⚡

View Form 4 on SEC.gov

ORBIMED ADVISORS LLC

Director

Sale

Date

Feb 2

Shares

1,890

Price

$44.57

Value

$84K

View Form 4 on SEC.gov

ORBIMED ADVISORS LLC

Director

Sale

Date

Feb 3

Shares

29,063

Price

$44.58

Value

$1.30M ⚡

View Form 4 on SEC.gov

TPG GP A, LLC

10 percent owner

Sale

Date

Jan 22

Shares

250,000

Price

$40.00

Value

$10.00M ⚡

View Form 4 on SEC.gov

⚡ = value ≥ $1M · Award/Option price shows — · formType=4 · securityName=Common Stock · url → sec.gov/Archives/edgar

1 / 4

Source: SEC EDGAR · Form 4 filings · ⚡ = value ≥ $1M · Award/Option price shows —

About SION insider trading

SION insider trades

Sionna Therapeutics, Inc. (SION) insider trading data is sourced from SEC Form 4 filings submitted by corporate insiders, including RA CAPITAL MANAGEMENT, L.P. (Director), Thompson Peter A. (Director), ORBIMED ADVISORS LLC (Director). Over the past 12 months, 5 insiders have filed transactions with the SEC. SION insiders have been primarily selling, which may reflect pre-scheduled Rule 10b5-1 plan executions.

For Sionna Therapeutics, Inc.'s institutional ownership breakdown and insider ownership percentage, see the Ownership tab → Ownership tab →

Buy/Sell signal logic
acquisitionOrDisposition field:
A = Acquisition (buy) · D = Disposition (sell)
RSU vesting (M-Exempt) excluded from sentiment
Form 4SEC filing required within 2 business days of any insider transaction
10b5-1Pre-scheduled trading plan that allows insiders to sell on autopilot
Open MktDirect purchase or sale on the open market (excludes awards, options)

Frequently asked questions

SION insider trading · 5 questions

The insiders of Sionna Therapeutics, Inc. (SION) include executives and directors such as RA CAPITAL MANAGEMENT, L.P. (Director), Thompson Peter A. (Director), ORBIMED ADVISORS LLC (Director), among others. Over the past 12 months, 5 insiders have filed Form 4 transactions with the SEC. Insider transactions are required to be reported within 2 business days of the trade date.

SION board member insider tradingwho are SION insidersSION insider rosterSionna Therapeutics, Inc. executives insider activity

Source: FMP /stable/insider-trading/search · SEC EDGAR Form 3 & 4 · acquisitionOrDisposition A=Buy, D=Sell · RSU vesting (M-Exempt) excluded from sentiment bar · As of Jun 8, 2026