Spyre Therapeutics, Inc.
Spyre Therapeutics, Inc. (SYRE) Stock Forecast & Analyst Price Target
Wall Street consensus, 12-month price targets, model projections, and EPS/revenue estimates — from analyst data and price history.
syre · stock forecast · 11 analysts (3M) · FMP · updated Jun 8, 2026
Analyst Rating & Consensus
Based on 11 Wall Street analysts in the past 3 months
Buy
11 analysts
consensus
Rating Breakdown
12-Month Price Target
High
$115
Consensus
$86.64
+20.9% upside
Low
$49.00
Median: $90 · Last Close: $71.66
12-Month Price Target Forecast
Historical closing prices + analyst 12-month price target forecast cone
Consensus Target
$86.64
20.9% upside
High Target
$115
60.5%
Low Target
$49
-31.6%
Current Price
$71.66
as of today
Based on analyst price targets, the SYRE stock price prediction for the next 12 months ranges from $49 to $115. The consensus SYRE price forecast of $86.64 implies 20.9% upside from the current price of $71.66.
Short-Term Price Prediction
BullAlgorithmically generated · Updated daily
| Date | Predicted Price | Change |
|---|---|---|
| 2026-06-09 | $71.73 | ↑ 0.09% |
1-day model range: $71.22–$72.23. Peak: $72.23 (+0.09%).
Long-Term Stock Price Prediction
Annual stock price forecast · 2027 / 2028 / 2029 / 2030 / 2031
| Year | Avg Price | Change |
|---|---|---|
| 2027 | $124 | +73.0% |
| 2028 | $178 | +148.8% |
| 2029 | $225 | +214.2% |
| 2030 | $261 | +263.8% |
| 2031 | — | +298.2% |
Stock Forecast Based on Technical Analysis
14 TA signals (SMA×6 + EMA×6 + RSI + MACD) · EEAT method transparency
Market Sentiment
NEUTRAL
Based on 14 technical indicators
Refreshes daily from EOD close
Moving Averages · SYRE · Jun 8, 2026
Latest Analyst Ratings & Upgrades
| Date | Brokerage | Action | Rating |
|---|---|---|---|
| 2026-06-04 | Deutsche Bank | Maintains | Buy→Buy |
| 2026-05-06 | Stifel | Maintains | Buy→Buy |
| 2026-05-06 | Citigroup | Maintains | Buy→Buy |
| 2026-04-17 | Jones Trading | Maintains | Buy→Buy |
| 2026-04-14 | Deutsche Bank | Maintains | Buy→Buy |
| 2026-04-14 | Wedbush | Maintains | Outperform→Outperform |
| 2026-04-14 | Wells Fargo | Maintains | Overweight→Overweight |
| 2026-04-14 | Baird | Maintains | Outperform→Outperform |
| 2026-04-13 | Leerink Partners | Maintains | Outperform→Outperform |
| 2026-04-13 | BTIG | Maintains | Buy→Buy |
Wall Street analysts have recently issued updated ratings on Spyre Therapeutics, Inc. (SYRE) stock. Of the recent 26 rating actions, 2 were upgrades and 0 were downgrades. 11 analysts currently cover SYRE.
Analyst Recommendation Trends
SYRE analyst recommendation trends show stable buy-side sentiment over the past 6 months. Buy rating actions changed from 1 to 1 per month.
Financial Forecast: EPS & Revenue Estimates
Revenue This Year
$0M
↓ 55.7% YoY
Revenue Next Year
$0M
↑ 88.1% YoY
EPS This Year
$-2.93
EPS Next Year
$-3.19
↑ 8.6% YoY
EPS ForecastReported vs Estimated
Analysts forecast SYRE EPS of $-2.93 for the current fiscal year, based on estimates from 10 analysts. The SYRE revenue forecast is $0M for the current year. These are analyst consensus estimates via FMP / S&P Global.
About Forecast & Price Prediction
The SYRE stock forecast is supported by two independent data sources: analyst consensus ratings from 11 Wall Street analysts (S&P Global / FMP), and technical analysis calculated from historical EOD price data. The consensus SYRE price target is $86.64 (+20.9% upside), with an analyst consensus of Buy.
The SYRE short-term stock prediction for tomorrow is $71.73 (+0.09%). The SYRE stock price prediction for 2027 estimates an average of $124. The SYRE stock prediction for 2030 projects a range of $241–$281.
Spyre Therapeutics, Inc. trades on NASDAQ under the ticker SYRE. The SYRE stock outlook for 2027 is broadly positive, supported by a Buy consensus among 100% of covering analysts.
Frequently asked questions
SYRE forecast · 8 questionsAccording to 11 Wall Street analysts, the average 12-month SYRE price target is $86.64, with a high forecast of $115.00 and a low of $49.00. The median price target is shown in the chart above when available. This implies +20.9% potential upside from the current price of $71.66.
· Analyst data: Financial Modeling Prep (FMP) · S&P Global Market Intelligence · Technical analysis: FMP /historical-price-eod/light · Updated: Hourly (analyst) · Daily (technical)
⚠ This information is provided for informational purposes only and does not constitute investment advice. Short-term and long-term price predictions are algorithmically generated and carry significant uncertainty. Past performance does not guarantee future results. Always conduct your own due diligence before making investment decisions.