Companies: 10,795·Total market cap: $144.5T
Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.

IONSNASDAQHealthcare● Active
$73.67
$-0.82(-1.09%)
Market Cap$12.2B
P/E Ratio—
52W High$86.74
52W Low$34.78
Cash on HandFinancialsRevenue

Ionis Pharmaceuticals, Inc. (IONS) Cash on Hand — Cash & Short-Term Investments

Cash & cash equivalents plus short-term investments from the balance sheet, YoY change, and net cash vs debt context.

IONS · cash on hand · updated Dec 31, 2025

Core cash position

Cash & Short-Term Investments (CCE + ST Investments)
$2.68B▲ +16.5% vs prior year
FY · as of Dec 31, 2025 · Reported in USD
Cash & Cash Equiv. (CCE)
$372.3M
cashAndCashEquivalents
Short-Term Investments
$2.30B
shortTermInvestments
YoY Change vs Prior Year
+16.5%
vs prior fiscal year
Latest Quarter
$1.92B
Q1 2026
Data Scope & Methodology

Cash on Hand = Cash & Cash Equivalents (CCE) + Short-Term Investments, as reported on the balance sheet (10-K/10-Q). Also referred to as cash reserves or cash position. Not free cash flow.

Source: FMP /balance-sheet-statement · SEC 10-K / 10-Q · Reported in USD

Source: FMP /balance-sheet-statement · SEC 10-K / 10-Q · USDUpdated: December 31, 2025

Net cash vs debt

Cash & ST Investments$2.68BCash on Hand
Total Debt$2.61BTotal Debt
Net Cash / Net Debt+$62.7MNet Cash Position
Cash vs Debt Ratio
Cash 51%Debt 49%

Ionis Pharmaceuticals, Inc. has a net cash position of $62.7M, holding more cash than debt.

Net Cash = Cash & ST Investments − Total Debt$2.68B − $2.61B = +$62.7M

Cash on hand history

YoY Increase
YoY Decrease
Latest Year
IONS annual cash on hand history · Cash & Short-Term Investments · Source: FMP /balance-sheet-statement

Annual cash on hand by year

DateCash & ST InvestmentsYoY Change
Dec 31, 2025Latest$2.68B+16.5%
Dec 31, 2024$2.30B-1.4%
Dec 31, 2023$2.33B+16.7%
Dec 31, 2022$2.00B-6.4%
Dec 31, 2021$2.13B+12.7%
IONS cash on hand annual historical data · Cash & Short-Term Investments per balance sheet (10-K/10-Q) · Reported in USD · Source: FMP /balance-sheet-statement

Healthcare Sector Cash Reserves Comparison

#CompanyCash & ST Inv.Cash/MCap
#1
UnitedHealth Group Incorporated
UnitedHealth Group Incorporated
UNH
$28.12B7.7%#2
Johnson & Johnson
Johnson & Johnson
JNJ
$20.10B3.6%#3
Eli Lilly and Company
Eli Lilly and Company
LLY
$7.27B0.7%#4
AbbVie Inc.
AbbVie Inc.
ABBV
$5.26B1.3%
#5
Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc.YOU
IONS
$2.68B22.1%
Healthcare sector cash reserves · Source: FMP /balance-sheet-statement + /profile · Sorted by Cash desccompanies with most cash on hand →

About cash on hand & methodology

Ionis Pharmaceuticals, Inc. (IONS) cash on hand as of December 31, 2025 is $2.68B, comprising $372.3M in cash and cash equivalents (CCE) plus $2.30B in short-term investments — reported as Ionis Pharmaceuticals, Inc. cash and short-term investments on the balance sheet (10-K filing). Also referred to as Ionis Pharmaceuticals, Inc. cash reserves or cash position.

Ionis Pharmaceuticals, Inc. annual cash on hand history shows increased +16.5% in 2025: increased +16.5% in 2025. Ionis Pharmaceuticals, Inc. cash reserves in 2025 reflect the company's capital allocation strategy.

Ionis Pharmaceuticals, Inc. carries total debt of $2.61B against cash of $2.68B, resulting in a net cash position of +$62.7M. For the full balance sheet, see the Financials → Balance Sheet tab.

Figures tie to SEC 10-K/10-Q balance sheet disclosures and FMP /balance-sheet-statement where noted.
Financial statementsFree cash flowNet incomeRevenueMarket capP/E ratioEarningsPrice history

Frequently asked questions

IONS cash on hand · 5 questions

As of December 31, 2025, Ionis Pharmaceuticals, Inc. (IONS) has $2.68B in cash on hand — defined as cash and short-term investments on the balance sheet. This includes $372,260,000 in cash and cash equivalents (CCE) plus $2.30B in short-term investments. Latest quarter (March 31, 2026): $1.92B. Data sourced from the annual 10-K filing via FMP.

IONS cash on handIONS cash reservesIONS cash 2025how much cash does IONS have

▸ Source: FMP /balance-sheet-statement · US GAAP · Ionis Pharmaceuticals, Inc. · Ionis Pharmaceuticals, Inc. SEC 10-K & 10-Q filings · US GAAP · Last updated: December 31, 2025