Lexicon Pharmaceuticals, Inc.
Lexicon Pharmaceuticals, Inc. (LXRX) Stock Ownership
Institutional vs insider vs public ownership from 13F and float data — top holders, activity, and insider trades below.
SEC 13F · FMP · LXRX · as of Sep 30, 2025
Ownership Breakdown
131
Institutional Holders
▲ 2 vs Q2
$347.67M
Total Inst. Value
▲ $104.67M vs Q2
444.20M
Shares Outstanding
freeFloat 47.17%
257.54M
13F Shares Held
▲ 1.19M vs Q2
Institutional ownership = 13F shares ÷ total outstanding. Insider % = 100 − free float. Public % = free float − institution %. Data: FMP /symbol-positions-summary + /shares-float + SEC EDGAR.
Top Institutional Holders
LXRX largest shareholders · institutional ownership
Q3 2025 · SEC 13F
Showing top 10 holders
| Holder | Shares | % Owned | Weight | Value | Reported | Change |
|---|---|---|---|---|---|---|
ARTAL GROUP S.A. pharmaceutical preparations | 136.18M | 37.48% | 37.48% | $183.84B | Nov 12, 2025 | — held |
SIREN, L.L.C. pharmaceutical preparations | 38.92M | 10.71% | 10.71% | $52.54B | Nov 13, 2025 | — held |
FMR LLC pharmaceutical preparations | 38.68M | 10.65% | 10.65% | $52.22B | Nov 13, 2025 | ▲ 542.2K |
VANGUARD GROUP INC pharmaceutical preparations | 9.52M | 2.62% | 2.62% | $12.85B | Nov 7, 2025 | ▲ 670.8K |
MILLENNIUM MANAGEMENT LLC pharmaceutical preparations | 3.83M | 1.05% | 1.05% | $5.17B | Nov 14, 2025 | ▲ 2.19M |
BLACKROCK, INC. pharmaceutical preparations | 3.39M | 93.45% | 93.45% | $4.58B | Nov 12, 2025 | ▲ 40.3K |
SESSA CAPITAL IM, L.P. pharmaceutical preparations | 3.00M | 82.58% | 82.58% | $4.05B | Nov 14, 2025 | — held |
CITADEL ADVISORS LLC pharmaceutical preparations | 2.63M | 72.50% | 72.50% | $3.56B | Nov 14, 2025 | ▲ 2.63M |
CIBC PRIVATE WEALTH GROUP, LLC pharmaceutical preparations | 2.40M | 66.07% | 66.07% | $3.24B | Nov 24, 2025 | ▼ 50.1K |
pharmaceutical preparations | 2.40M | 66.07% | 66.07% | $3.24B | Nov 12, 2025 | NEW |
Data from SEC Form 13F filings. Ownership bar normalised to largest holder. Change flags: isNew / isSoldOut / changeInSharesNumber (FMP extract-analytics/holder).
Institutional Activity
Q3 2025 vs prior quarter
Q3 2025
20
Increased
+7.58M shares6
New Positions
first time holders19
Decreased
−7.85M shares0
Sold Out
fully exitedNet shares change (top 50)
275.1K
+7.58M / −7.85M
Net new holders
+7
6 new / 0 exited
Based on top 50 institutional holders by position size. Fields: isNew, isSoldOut, changeInSharesNumber (FMP extract-analytics/holder, limit=50).
Insider Buying vs Selling
LXRX insider trading · insider activity
Source: SEC Form 4
23
Buy transactions
8
Sell transactions
2.88
Buy/Sell ratio
$1M
Total disposed
Recent Insider Transactions
Showing 10 most recent · Common Stock only
| Name · Role | Date | Type | Shares | Price | Value | After Trans. | Filing |
|---|---|---|---|---|---|---|---|
Artal Participations S.a r.l.
| Apr 30, 2026 | Award | 408,434.7 | — | — | 408.4K | Form 4 ↗ |
Amouyal Philippe director | May 1, 2026 | Award | 43,478 | $1.61 | $70.0K | 43.5K | Form 4 ↗ |
Amouyal Philippe director | May 1, 2026 | Award | 35,714 | — | — | 35.7K | Form 4 ↗ |
SOBECKI CHRISTOPHER J director | May 1, 2026 | Award | 43,478 | $1.61 | $70.0K | 43.5K | Form 4 ↗ |
Source: /insider-trading/search (FMP stable). Buy/Sell direction: acquisitionOrDisposition A=Buy, D=Sell. RSU vesting (M-Exempt) excluded from sentiment bar. All data from SEC EDGAR public filings.
About institutional & insider ownership
Lexicon Pharmaceuticals, Inc. (LXRX) is primarily owned by institutional investors, who hold approximately 58.0% of total shares outstanding. Company insiders own approximately 52.83%, while retail and public investors account for the remaining 0.00%.
The largest institutional shareholder of Lexicon Pharmaceuticals, Inc. is ARTAL GROUP S.A., holding approximately 136.18 million shares — equal to 37.48% of outstanding shares — as of September 30, 2025.
A total of 131 institutional investors currently hold LXRX stock, with a combined institutional value of approximately $347,669,854 as of the most recent 13F filing period.
Frequently asked questions
LXRX ownershipLexicon Pharmaceuticals, Inc. (LXRX) is primarily owned by institutional investors, who hold approximately 58.0% of shares. The largest shareholder is ARTAL GROUP S.A. with a 37.48% stake. Company insiders hold 52.83%. Data sourced from SEC Form 13F as of September 30, 2025.