OPKO Health, Inc.

OPKNASDAQHealthcare● Active

$1.44

$-0.00(-0.16%)

Market Cap$1.1B

P/E Ratio—

52W High$1.6

52W Low$0.98

Avg Volume2.6M

Open$1.45

Beta1.49

Insider Trades Ownership Employees

OPKO Health, Inc. (OPK) Insider Trading

Form 4 buy vs sell counts, ratio, and sentiment — switch this quarter or last 12 months; chart and transactions below.

SEC EDGAR · FMP · OPK · as of Jun 8, 2026

Activity summary

Buy transactions

P-Purchase only

Sell transactions

12 Months

Buy/Sell ratio

∞

Buy/Sell (by trades)

Overall sentiment

BULLISH

↑ Buy 100%Active transactions only · RSU vesting excluded0% Sell ↓

OPKO Health, Inc. insiders have been net buyers of shares over the past 12 Months, which may signal confidence in the company's outlook.

▸ Source: SEC EDGAR · Form 3 & 4 · via Financial Modeling Prep · Buy = P-Purchase only · Sell = S-Sale only

As of Jun 8, 2026

OPK insider buying and selling by quarter

OPK insider selling · OPK insider buying stocks · quarterly insider activity

Total insider buying (incl. awards)Total insider selling

3.4M1.7M0

2024 Q2

2024 Q3

2024 Q4

2025 Q1

2025 Q2

2025 Q3

2025 Q4

2026 Q1

Mobile shows last 4Q · Desktop shows full 8Q

▸ Source: SEC EDGAR · Form 3 & 4 · via Financial Modeling Prep · last 8 quarters

As of Jun 8, 2026

Active insiders

Most active in past 12 months · OPK ceo insider trading

Showing all insiders · Click a card to filter the transactions table below

▸ Aggregated from reportingName · top 5 by trade count (12M) · no extra API

Recent insider transactions

OPK executive sell shares · OPK board member insider trading · OPK insider trading SEC filing

Showing 72 most recent · Common Stock · Form 4 only

Scroll horizontally to see all columns

Date	Insider	Type	Shares	Price	Value	After trans.	Filing
Mar 20, 2026	PAGANELLI JOHN A Director	Purchase	10,000	$1.14	$11K	394,340	Form 4
Nov 21, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	192,870	$1.33	$257K	216,706,448	Form 4
Nov 21, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	191,490	$1.33	$255K	216,513,578	Form 4
Nov 21, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	89,375	$1.32	$118K	216,322,088	Form 4
Nov 21, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	3,894	$1.32	$5K	216,232,713	Form 4
Nov 21, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	102,371	$1.30	$133K	216,228,819	Form 4
Nov 20, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	13,664	$1.35	$18K	216,126,448	Form 4
Nov 20, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	1,757	$1.34	$2K	216,112,784	Form 4
Nov 20, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	24,579	$1.34	$33K	216,111,027	Form 4
Nov 20, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	161,818	$1.33	$216K	216,086,448	Form 4
Nov 20, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	211,948	$1.33	$282K	215,924,630	Form 4
Nov 20, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	47,105	$1.32	$62K	215,712,682	Form 4
Nov 20, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	119,129	$1.32	$157K	215,665,577	Form 4
Nov 19, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	155,496	$1.32	$205K	215,546,448	Form 4
Nov 19, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	198,904	$1.31	$262K	215,390,952	Form 4
Nov 19, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	66,504	$1.31	$87K	215,192,048	Form 4
Nov 19, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	12,993	$1.30	$17K	215,125,544	Form 4
Nov 19, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	30,082	$1.30	$39K	215,112,551	Form 4
Nov 19, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	21,236	$1.29	$28K	215,082,469	Form 4
Nov 19, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	300	$1.29	$387	215,061,233	Form 4
Nov 19, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	58,160	$1.28	$75K	215,060,933	Form 4
Nov 19, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	36,325	$1.28	$46K	215,002,773	Form 4
Nov 18, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	33,572	$1.29	$43K	214,966,448	Form 4
Nov 18, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	1	$1.29	$1	214,932,876	Form 4
Nov 18, 2025	FROST PHILLIP MD ET AL CEO & Chairman · Director	Purchase	83,556	$1.28	$107K	214,932,875	Form 4

PAGANELLI JOHN A

Director

Purchase

Date

Mar 20

10,000

Price

$1.14

Value

$11K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 21

192,870

Price

$1.33

Value

$257K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 21

191,490

Price

$1.33

Value

$255K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 21

89,375

Price

$1.32

Value

$118K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 21

3,894

Price

$1.32

Value

$5K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 21

102,371

Price

$1.30

Value

$133K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 20

13,664

Price

$1.35

Value

$18K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 20

1,757

Price

$1.34

Value

$2K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 20

24,579

Price

$1.34

Value

$33K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 20

161,818

Price

$1.33

Value

$216K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 20

211,948

Price

$1.33

Value

$282K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 20

47,105

Price

$1.32

Value

$62K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 20

119,129

Price

$1.32

Value

$157K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 19

155,496

Price

$1.32

Value

$205K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 19

198,904

Price

$1.31

Value

$262K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 19

66,504

Price

$1.31

Value

$87K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 19

12,993

Price

$1.30

Value

$17K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 19

30,082

Price

$1.30

Value

$39K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 19

21,236

Price

$1.29

Value

$28K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 19

300

Price

$1.29

Value

$387

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 19

58,160

Price

$1.28

Value

$75K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 19

36,325

Price

$1.28

Value

$46K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 18

33,572

Price

$1.29

Value

$43K

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 18

Price

$1.29

Value

View Form 4 on SEC.gov

FROST PHILLIP MD ET AL

CEO & Chairman · Director

Purchase

Date

Nov 18

83,556

Price

$1.28

Value

$107K

View Form 4 on SEC.gov

⚡ = value ≥ $1M · Award/Option price shows — · formType=4 · securityName=Common Stock · url → sec.gov/Archives/edgar

1 / 3

▸ Source: SEC EDGAR · Form 4 filings · ⚡ = value ≥ $1M · Award/Option price shows —

About OPK insider trading

OPK insider trades

OPKO Health, Inc. (OPK) insider trading data is sourced from SEC Form 4 filings submitted by corporate insiders, including FROST PHILLIP MD ET AL (CEO & Chairman · Director), PAGANELLI JOHN A (Director). Over the past 12 months, 2 insiders have filed transactions with the SEC. OPK insiders have been primarily buying, which may reflect pre-scheduled Rule 10b5-1 plan executions.

For OPKO Health, Inc.'s institutional ownership breakdown and insider ownership percentage, see the Ownership tab → Ownership tab →

Buy/Sell signal logic

acquisitionOrDisposition field:

A = Acquisition (buy) · D = Disposition (sell)

RSU vesting (M-Exempt) excluded from sentiment

Form 4SEC filing required within 2 business days of any insider transaction

10b5-1Pre-scheduled trading plan that allows insiders to sell on autopilot

Open MktDirect purchase or sale on the open market (excludes awards, options)

Ownership SEC filings Financial statements Price history Forecast & ratings Earnings

Frequently asked questions

OPK insider trading · 5 questions

The insiders of OPKO Health, Inc. (OPK) include executives and directors such as FROST PHILLIP MD ET AL (CEO & Chairman · Director), PAGANELLI JOHN A (Director), among others. Over the past 12 months, 2 insiders have filed Form 4 transactions with the SEC. Insider transactions are required to be reported within 2 business days of the trade date.

OPK board member insider tradingwho are OPK insidersOPK insider rosterOPKO Health, Inc. executives insider activity

▸ Source: FMP /stable/insider-trading/search · SEC EDGAR Form 3 & 4 · acquisitionOrDisposition A=Buy, D=Sell · RSU vesting (M-Exempt) excluded from sentiment bar · As of Jun 8, 2026