Companies: 10,795·Total market cap: $144.5T
Prime Medicine, Inc.

Prime Medicine, Inc.

PRMENASDAQHealthcare● Active
$2.97
$-0.10(-3.10%)
Market Cap$535530739
P/E Ratio—
52W High$6.94
52W Low$1.305
Cash on HandFinancialsRevenue

Prime Medicine, Inc. (PRME) Cash on Hand — Cash & Short-Term Investments

Cash & cash equivalents plus short-term investments from the balance sheet, YoY change, and net cash vs debt context.

PRME · cash on hand · updated Dec 31, 2025

Core cash position

Cash & Short-Term Investments (CCE + ST Investments)
$177.7M▼ -6.7% vs prior year
FY · as of Dec 31, 2025 · Reported in USD
Cash & Cash Equiv. (CCE)
$63.0M
cashAndCashEquivalents
Short-Term Investments
$114.6M
shortTermInvestments
YoY Change vs Prior Year
-6.7%
vs prior fiscal year
Latest Quarter
$135.5M
Q1 2026
Data Scope & Methodology

Cash on Hand = Cash & Cash Equivalents (CCE) + Short-Term Investments, as reported on the balance sheet (10-K/10-Q). Also referred to as cash reserves or cash position. Not free cash flow.

Source: FMP /balance-sheet-statement · SEC 10-K / 10-Q · Reported in USD

Source: FMP /balance-sheet-statement · SEC 10-K / 10-Q · USDUpdated: December 31, 2025

Net cash vs debt

Cash & ST Investments$177.7MCash on Hand
Total Debt$116.4MTotal Debt
Net Cash / Net Debt+$61.3MNet Cash Position
Cash vs Debt Ratio
Cash 60%Debt 40%

Prime Medicine, Inc. has a net cash position of $61.3M, holding more cash than debt.

Net Cash = Cash & ST Investments − Total Debt$177.7M − $116.4M = +$61.3M

Cash on hand history

YoY Increase
YoY Decrease
Latest Year
PRME annual cash on hand history · Cash & Short-Term Investments · Source: FMP /balance-sheet-statement

Annual cash on hand by year

DateCash & ST InvestmentsYoY Change
Dec 31, 2025Latest$177.7M-6.7%
Dec 31, 2024$190.4M+56.5%
Dec 31, 2023$121.7M-58.6%
Dec 31, 2022$293.9M+9.0%
Dec 31, 2021$269.6M+405.6%
PRME cash on hand annual historical data · Cash & Short-Term Investments per balance sheet (10-K/10-Q) · Reported in USD · Source: FMP /balance-sheet-statement

Healthcare Sector Cash Reserves Comparison

#CompanyCash & ST Inv.Cash/MCap
#1
UnitedHealth Group Incorporated
UnitedHealth Group Incorporated
UNH
$28.12B7.6%#2
Johnson & Johnson
Johnson & Johnson
JNJ
$20.10B3.6%#3
Eli Lilly and Company
Eli Lilly and Company
LLY
$7.27B0.7%#4
AbbVie Inc.
AbbVie Inc.
ABBV
$5.26B1.3%
#5
Prime Medicine, Inc.
Prime Medicine, Inc.YOU
PRME
$177.7M33.1%
Healthcare sector cash reserves · Source: FMP /balance-sheet-statement + /profile · Sorted by Cash desccompanies with most cash on hand →

About cash on hand & methodology

Prime Medicine, Inc. (PRME) cash on hand as of December 31, 2025 is $177.7M, comprising $63.0M in cash and cash equivalents (CCE) plus $114.6M in short-term investments — reported as Prime Medicine, Inc. cash and short-term investments on the balance sheet (10-K filing). Also referred to as Prime Medicine, Inc. cash reserves or cash position.

Prime Medicine, Inc. annual cash on hand history shows decreased -6.7% in 2025: decreased -6.7% in 2025. Prime Medicine, Inc. cash reserves in 2025 reflect the company's capital allocation strategy.

Prime Medicine, Inc. carries total debt of $116.4M against cash of $177.7M, resulting in a net cash position of +$61.3M. For the full balance sheet, see the Financials → Balance Sheet tab.

Figures tie to SEC 10-K/10-Q balance sheet disclosures and FMP /balance-sheet-statement where noted.
Financial statementsFree cash flowNet incomeRevenueMarket capP/E ratioEarningsPrice history

Frequently asked questions

PRME cash on hand · 5 questions

As of December 31, 2025, Prime Medicine, Inc. (PRME) has $177,680,000 in cash on hand — defined as cash and short-term investments on the balance sheet. This includes $63,032,000 in cash and cash equivalents (CCE) plus $114,648,000 in short-term investments. Latest quarter (March 31, 2026): $135,497,000. Data sourced from the annual 10-K filing via FMP.

PRME cash on handPRME cash reservesPRME cash 2025how much cash does PRME have

▸ Source: FMP /balance-sheet-statement · US GAAP · Prime Medicine, Inc. · Prime Medicine, Inc. SEC 10-K & 10-Q filings · US GAAP · Last updated: December 31, 2025