Prime Medicine, Inc.

PRMENASDAQHealthcare● Active

$2.96

$-0.10(-3.27%)

Market Cap$534627652

P/E Ratio—

52W High$6.94

52W Low$1.305

Avg Volume2.4M

Open$3.14

Beta2.31

Free Cash Flow Financials Revenue

Prime Medicine, Inc. (PRME) Free Cash Flow & Analysis

Annual & trailing free cash flow, FCF margin, YoY change, valuation ratios, and peer context.

PRME · free cash flow · updated Jun 8, 2026

Core FCF metrics

PRME · FCF · TTM · margin & CAGR

Free cash flow was −$167.1M for FY2025 (fiscal year ending 2025-12-31), down 28.4% year-over-year

FY2025 Free Cash Flow−$167.1M▼ -28.4% YoY

Trailing 12M (TTM)−$158.7Mtrailing 4 quarters sum

FCF Margin< −999%−$167.1M ÷ revenue

3-Year CAGRN/AN/A — contains negative FCF

5-Year CAGRN/AN/A — contains negative FCF

FormulaFCF = Operating Cash Flow − Capital ExpendituresTTM = trailing 4 quarters sumCAGR → N/A if either endpoint ≤ 0

Source: FMP /cash-flow-statement · SEC 10-K / 10-Q · USDUpdated: Jun 8, 2026

Annual free cash flow history

FCF ($B, upper) · YoY Growth % (lower)

Positive FCFNegative FCF

Free Cash Flow

YoY Growth %

Annual free cash flow data

PRME · free cash flow history · annual / quarterly

Fiscal YearOperating CFCapExFree Cash FlowYoY ChangeFCF Margin

FY2025Latest−$162.6M(5M)−$167.1M▼ 28.4%—

FY2024−$122.9M(7M)−$130.2M▲ +25.3%—

FY2023−$165.4M(9M)−$174.1M▼ 17.7%—

FY2022−$131.8M(16M)−$147.9M▼ 286.9%—

FY2021−$34.1M(4M)−$38.2M▼ 518.3%—

FCF = Operating Cash Flow − Capital Expenditures · CapEx shown as (negative) · Source: SEC filings via FMP

FCF valuation metrics

PRME · P/FCF · FCF yield · FCF per share

Prime Medicine, Inc. (PRME) reported negative free cash flow of −$0.17B. FCF-based valuation ratios are not meaningful when FCF is negative.

FCF Yield (TTM)

N/A

Free Cash Flow ÷ Market Cap

per FMP freeCashFlowYieldTTM definition

FCF per Share (TTM)

N/A

TTM FCF ÷ Shares Outstanding

Price / FCF

N/A

Share Price ÷ FCF per Share

EV / FCF (TTM)

N/A

Enterprise Value basis

FCF-based valuation ratios are only meaningful when free cash flow is positive. Negative FCF indicates capital expenditures exceeded operating cash flow.

Source: FMP /key-metrics-ttm · /cash-flow-statement Q · /income-statementFY2025 · 2025-12-31

Cash flow statement summary

PRME · cash flow statement · operating / investing / financing

For FY2025, Prime Medicine, Inc. generated −$162.6M in operating cash flow and spent 5M in capital expenditures, yielding −$167.1M in free cash flow.

Operating Activities

−$162.6M

Cash from core business operations

2025-12-31

Investing Activities

−$108.8M

CapEx, acquisitions & investments

2025-12-31

Financing Activities

+$151.5M

Buybacks, dividends & debt

2025-12-31

FCF FormulaOperating CF (−$162.6M) − |CapEx| (5M) = FCF (−$167.1M)

For the complete Operating / Investing / Financing line-item breakdown:

View Full Cash Flow Statement →

Free cash flow vs peers (Healthcare)

PRME vs peers · FCF

#CompanyFree Cash FlowYoYFCF MarginRelative

Prime Medicine, Inc.YOU

PRME

−$167.1M-28.4%-3607.4%

Loss

UnitedHealth Group Incorporated

UNH

$16.07B-22.4%3.6%

82%

Eli Lilly and Company

LLY

$8.97B+2065.6%13.8%

46%

Healthcare · Sorted by FCF · FMP /cash-flow-statementFull FCF Rankings →

About Free Cash Flow & Methodology

Prime Medicine, Inc. (PRME) reported free cash flow of −$167.1M for FY2025 (fiscal year ending 2025-12-31), down 28.4% year-over-year.

Prime Medicine, Inc. has reported negative free cash flow in recent periods, indicating capital expenditures have exceeded operating cash flow. Data available for 7 fiscal years.

Data sourced from FMP /cash-flow-statement · SEC 10-K / 10-Q · USD.

Q&A and summaries align with SEC 10-K/10-Q cash flow disclosures and FMP /cash-flow-statement where noted.

Revenue Financial statements Net income Earnings Forecast Price history Market cap Cash on hand P/E ratio

Frequently asked questions

PRME free cash flow · 8 questions

Prime Medicine, Inc. free cash flow was −$167.1M for FY2025, down 28.4% year-over-year. On a trailing twelve-month (TTM) basis, free cash flow stands at −$158.7M.

PRME free cash flowPRME FCFPRME FCF 2025PRME free cash flow TTM

▸ Source: FMP /cash-flow-statement · US GAAP · Prime Medicine, Inc. · Prime Medicine, Inc. SEC 10-K & 10-Q filings · US GAAP · Last updated: Jun 8, 2026