Spyre Therapeutics, Inc.

SYRENASDAQHealthcare● Active

$71.60

$-2.05(-2.78%)

Market Cap$4.3B

P/E Ratio—

52W High$78.8

52W Low$13.93

Avg Volume1.1M

Open$75.53

Beta3.06

Employees Ownership Insider Trades

Spyre Therapeutics, Inc. (SYRE) Number of Employees – History & Annual Headcount

Annual SEC headcount, year-over-year change, and per-employee efficiency — chart and full history below.

SEC EDGAR · FMP · SYRE · as of Feb 19, 2026

Latest filing snapshot

102

+37+56.92%vs prior year

Spyre Therapeutics, Inc. (SYRE) employee data is sourced from the annual SEC 10-K filing. As of 2025, full-time employees only. Global consolidated headcount. View SEC filing ↗

SEC 10-K·Period end: 2025-12-31·Full-time · Global

Total Employees

102

Change (1Y)

+37

Growth % (1Y)

+56.92%

Revenue / Employee

—

Net Income / Employee

$-1.52M

Market Cap

$4.3B

SYRE Employee Count

2016 – 2025 · Annual · SEC filing

Source: SEC annual filings · Hover bar to view year data · Click to view original filing

Employees History

Filing Date	Period End	Employees	Change (1Y)	Growth (1Y)
2026-02-19	2025-12-31	102	+37	+56.92%
2025-02-27	2024-12-31	65	+35	+116.67%
2024-02-29	2023-12-31	30	-39	-56.52%
2023-03-02	2022-12-31	69	-32	-31.68%
2022-03-08	2021-12-31	101	+11	+12.22%
2021-03-18	2020-12-31	90	+14	+18.42%
2020-02-24	2019-12-31	76	+15	+24.59%
2019-03-07	2018-12-31	61	+18	+41.86%
2018-03-13	2017-12-31	43	+13	+43.33%
2017-03-23	2016-12-31	30	—	—

▸ Source: SEC Annual Reports (Form 10-K / 20-F). Employee counts as of fiscal year end. Click the ↗ icon at the end of a row to open the original SEC filing in a new tab.

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SYRE

Spyre Therapeutics, Inc.YOU

102$4.3B

Source: /stock-peers + /profile.fullTimeEmployees · Click row → /employees · Sorted by headcount · SYRE peer comparison

About SYRE employees

SYRE Employees · Headcount

Spyre Therapeutics, Inc. (SYRE) employee data is sourced from the annual SEC 10-K filing. As of 2025, Spyre Therapeutics, Inc. had 102 full-time employees globally. Full-time employees only. Global consolidated headcount.

Spyre Therapeutics, Inc.'s workforce increased by 37 (56.92%) in 2025 compared to the prior fiscal year. The historical trend reflects the company's expansion and contraction cycles.

Revenue Financial statements Net income SEC filings Price history Forecast & ratings Ownership Earnings

Frequently Asked Questions

SYRE Employees · 5 questions

As of the latest SEC 10-K filing (2025), Spyre Therapeutics, Inc. had 102 full-time employees globally. This figure is sourced from the company's mandatory annual disclosure to the SEC.

Spyre Therapeutics, Inc. employee counthow many employees does Spyre Therapeutics, Inc. haveSYRE total employees 2025

▸ Data source: FMP /historical-employee-count · SEC EDGAR annual filings · As reported · Global consolidated headcount · As of 2026-02-19